Rasmussen\'s Encephalitis

Keyur P.

The human immune system is an amazing system that is constantly on the alert protecting us from
sicknesses. Thousands of white blood cells travel in our circulatory system destroying all foreign
substances that could cause harm to our body or to any of the millions of processes going on inside. Now
imagine a condition where this awesome system turns against the most complex organ in the human body,
the brain. Deadly as it is, this condition is known as Rasmussenís encephalitis.
The meaningful research on Rasmussenís encephalitis was begun (unintentionally) by Scott Rogers
and Lorise Gahring, two neurologists, who were at the time measuring the distribution of glutamate
receptors in the brain. Later on when more provocative information was found they enlisted the help of
James McNamara and Ian Andrews, epilepsy experts at Duke University Medical Center.
The details on Rasmussenís encephalitis were very bleak at the time when the men began their
research. All that was known is that Rasmussenís encephalitis was a degenerative disease of the brain
that caused seizures, hemiparesis, and dementia normally in the first ten years of life. The seizures that
were caused by Rasmussenís encephalitis were unstoppable by normal anti-seizure drugs used
conventionally. What the worst part of the disease was that the pathogenesis for it were not known and
even worse was how it developed.
The first clue was delivered when Rogers and Gahring were trying to register the distribution of the
glutamate receptors using antibodies, that tag on to the receptor itself. The proteins that make up the
glutamate receptors(GluR) are only found inside the blood brain barrier(BBB). Glutamate and a few
related amino acids are the dominant form of excitatory neurotransmitter in the central nervous system of
mammals. If one of these GluRs happens to wander into the actual bloodstream, that is outside the BBB,
it would be considered an outsider and destroyed immediately. So if these GluRs were put into the normal
blood stream then the immune system would produce antibodies which could then be used in the
searching for the glutamate receptors.
In order to test this theory the researchers injected the GluRs into the blood stream of a normal
healthy rabbit hoping to produce good results. At this point the experiment took a dramatic turn, after
receiving a few doses of the protein two of the three rabbits began to twitch, as though they were suffering
the pain of an epileptic seizure. Now the help of McNamara and Andrews was enlisted.
When McNamara and Andrews examined the brain tissue of the rabbits, they saw what seemed to be
a familiar inflammatory pattern, clumps of immune cells all around blood vessels. This description
exactly matched the description of persons suffering from Rasmussenís encephalitis, moreover something
as this would never be found in a healthy brain. A healthy brain has its blood capillaries enclosed in the
BBB membrane, so such a case as the one mentioned above would not be possible.
As protective as the BBB is, it can be breached by something like a head injury. What was
happening was that the antibodies which were out to get the GluR proteins were somehow finding a way
into the brain and directing an attack towards all GluR receptor proteins in the brain itself.
After some more examinations Rogers and McNamara decided that these attacks were the cause of
the seizures that are often experienced by sufferers of Ramussenís encephalitis. Then if the case is of
antibodies in the bloodstream, than sufferers of Ramussenís encephalitis should have them in their
bloodstream and healthy normal peoples shouldnít. When this was actually tested the results were
positive that Rasmussen sufferers did have these antibodies in their bloodstreams and healthy people did
not. These were not only the right kind of antibodies but, the very antibodies that caused the seizures in
people and rabbits. Thus when these antibodies were removed by plasma exchange(PEX) it caused a
temporary relief from the seizures but soon the body starts making more antibodies of the type and the
seizures start once again. After all the examinations two questions remained, why does the body mount
an immune response against one of its own brain proteins, and how do these antibodies get through the
What is thought